Is an essential vitamin during the metabolism of carbohydrates. When thiamine deficiency, the oxidation of the alpha-cetoacid affected, makes pyruvate concentration in the blood increases, help diagnose the condition lack of thiamine.Thiamine deficiency will cause beriberi (a disease numbness in line). Mild deficiency expression on nervous system (dry beriberi) such as inflammation of the peripheral nerves, sensory disorders, can increase costs or loss of sensation. Diminished muscle tone and can cause failure or paralysis of a branch. Severe deficiency causes bipolar disorder, depression, lack of initiative and poor memory as in brain diseases Wernicke and if treatment of late causing Korsakoff psychosis.
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