Hemolytic disease of the fetus and newborn is most commonly caused by anti-D alloantibody. It is usually seen in the Rhesus D (RhD)-negative mothers that have been previously sensitized. We report here a case of hemolytic disease of the fetus and newborn in a baby newborn caused by anti-D and anti-S alloantibodies, born to a mother who was RhD negative, but with no previous serological evidence of RhD alloimmunization.
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