The development cycle of Chlamydia trachomatis. Chlamydia trachomatis is an obligate intracellular pathogen which is located in a specific cell and has a two-phase development cycle140. An infectious, but metabolically inactive, elementary body (EB) is taken up by the mucosal epithelial cells. After introspective, EB is surrounded by an endosomal membrane to form an inclusive - a vacuole is formed by the endothelial path normal trading - which creates an intracellular niche permissive for the replication of C. trachomatis117. In the standard, EB turns into a larger body reticulate metabolic activities (RB), which divide by binary fission. Within 40-48 hours (hours), RBS transform back into EBS infection, which is then released from the vacuoles including neighboring cell infection. In the presence of growth inhibitors, interferon-γ example, intracellular C. trachomatis bacteria do not get a copy, persistent form, and this form of bacteria differentiate back into forms of infection after removal of the inhibitor.
đang được dịch, vui lòng đợi..