There are many factors, technological processes affect the quality of milk in the production process. In the process of assimilation which is considered an important step, is directly related to the stability of emulsion. The degree of effectiveness of the process of assimilation was assessed through indicators NIZO. In this study, the survey focused on conditions affected NIZO index after anabolic processes in the production process UHT milk and optimization of parameters by means of RSM (RSM) to obtain NIZO is the highest index. The results showed that the highest NIZO index, reached 79.66% with anabolic conditions are as follows: temperature assimilation (T0C) is 740C, the fat content in milk before assimilation (Fat) is 3, 24%, the pressure to assimilate level 1 (P1) is 179 bar, the pressure ratio between the two levels of assimilation (P2 / P1) of 2.1. The successful optimization of conditions affecting the efficient assimilation process is a prerequisite to help businesses optimize production processes, contributing to improving the quality of products.
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