kanamycin and streptomycin narrowest spectrum of drugs of this group, they have no effect on P. aeruginosa or Serratia. Tobramycinva gentamicin similar activity on Gram-negative bacilli, but Tobramicin have a greater effect on P. aeruginosa and Proteus spp, while stronger Gentamicin on Serratia. Amikacin and in some cases is Neltimicin, remain active on the gentamicin-resistant strains because the structure of these drugs is not a substrate of the enzyme inactivation of aminoglycosides many
undesirable effects (ADR)
and hearing loss renal failure is the most common two types of ADR. Both two types of ADR will become severe (irreversible deafness, renal tubular necrosis or interstitial nephritis) when used in patients with renal impairment, elderly people (reduced kidney function), or concomitant use of drugs and toxicity (vancomucin, furosemide, ..)
the ADR common allergens such as skin (you did, skin rash) or shocked too rash also met with this group of drugs.
đang được dịch, vui lòng đợi..
