Spinning disc reactor (SDR) is one

Spinning disc reactor (SDR) is one ofthe multifunctional devices
which provide fast and homogenous mixing in a continuous operation.
Past research studies proposed that SDR as an intensified
reactor for heat and mass transfer limitation process [1–5] and also
it is widely used for fast co-precipitation process such as precipitation
of silver, lithium carbonate, copper oxide and chitosan [6–9].
Basicprinciple of SDRis seemed similar like fallingfilmevaporators.
In the fallingfilm evaporator,thin falling liquidfilm on the tube wall
improves the heat transfer coefficient. Whereas in the case of SDR,
sheared thin film on the rotating disc is responsible for higher heat
and mass transfer coefficient [1,4,10,11]. Principally SDR is a horizontal
or vertical fast moving rotating disc in a circular chamber.
Whenliquidis introducedonthe centre of rotatingdisc, a thinliquid
Abbreviations: SDR, spinning disc reactor; NS-S, non-solvent to solvent; S-NS,
solvent and non-solvent; PDI, polydispersity index; PSD, particle size distribution;
PVP, polyvinylpyrilodine.
∗ Corresponding author. Tel.: [phone]; fax: [phone].
E-mail addresses: [e-mail], [e-mail]
(V.K. Rathod).
film appears on the disc surface under the influence of high centrifugalforce
whichprovides larger surface contact betweenmixing
fluid. At the same time, centrifugal force also responsible for shear
between disc surface and liquid leads to wave and ripple formation
on the film and generates large volume of smaller eddies throughout.
These phenomenon are responsible for speedy and uniform
mixing of fluid on the disc [7,12–14]. In the present work, SDR is
used for the continuous preparation of curcumin nanoparticles via
solvent–nonsolvent (S-NS) precipitation.
Curcumin is a yellow polyphenol hydrophobic compound
which is extracted from the rhizome of the herb Curcuma
longa. Curcumin has wide varieties of therapeutic application
such as an anticancer, anti-inflammatory, antioxidant, antiulcer,
immunomodulatory, wound healing, neuroprotective, and antiaging
agents [15,16]. These useful applications of curcumin are
limited by its hydrophobicity (solubility of pure curcumin in water
0.2 mg L−1). Hydrophobic nature of curcumin hinders its successful
use due to limited dissolution and hence lesser bioavailability.
Nanosizing is one of the attractive techniques amongst the most
commonly used methods to mitigate poor drug dissolution problem.
Reduced particle size by nanosizing increases surface area
and eventually enhances the solubility and bioavailability of the
poorly soluble drug component. Various approaches of nanosizing

Kết quả (Anh) 1:

Spinning disc reactor (SDR) is one ofthe multifunctional deviceswhich provide fast and homogenous mixing in a continuous operation.Past research studies proposed that SDR as an intensifiedreactor for heat and mass transfer limitation process [1-5] and alsoIt is widely used for fast co-precipitation process such as precipitationof silver, lithium carbonate, copper oxide and chitosan [6-9].Basicprinciple of SDRis seemed similar like fallingfilmevaporators.In the evaporator, thin fallingfilm falling liquidfilm on the tube wallimproves the heat transfer coefficient. Whereas in the case of SDR,sheared thin film on the rotating disc is responsible for higher heatand mass transfer coefficient [1, 4, 10.11]. Principally SDR is a horizontalor vertical fast moving rotating disc in a circular chamber.Whenliquidis introducedonthe rotatingdisc, a centre of thinliquidAbbreviations: SDR, spinning disc reactor; NS-S, non-solvent to solvent; S-NS,solvent and non-solvent; PDI, polydispersity index; Particle size distribution, PSD;PVP, polyvinylpyrilodine.∗ Corresponding author. Tel.: + 91 22 33612020; Fax: + 91 22 33611020.E-mail addresses: [e-mail], [e-mail](V.K. Rathod).the film appears on the disc surface under the influence of high centrifugalforcewhichprovides larger surface contact betweenmixingfluid. At the same time, the centrifugal force is also responsible for shearbetween disc surface and liquid leads to wave and ripple formationon the film and generates large volume of smaller eddies throughout.These phenomenon are responsible for speedy and uniformmixing of fluid on the disc [7.12-14]. In the present work, the SDR isused for the continuous preparation of curcumin nanoparticles viasolvent-nonsolvent (S-NS) precipitation.Curcumin is a yellow polyphenol hydrophobic compoundwhich is extracted from the rhizome of the herb CurcumaLonga. Curcumin has wide varieties of therapeutic applicationsuch as an anticancer, anti-inflammatory, antioxidant, antiulcer,immunomodulatory, wound healing, neuroprotective, and antiagingagents [15.16]. These useful applications of curcumin arelimited by its hydrophobicity (solubility of pure curcumin in water0.2 mg L − 1). Hydrophobic nature of curcumin hinders its successfuluse due to limited dissolution and hence lesser bioavailability.Nanosizing is one of the attractive techniques amongst the mostcommonly used methods to mitigate poor drug dissolution problem.Reduced particle size by nanosizing increases surface areaand eventually enhances the solubility and bioavailability of thepoorly soluble drug component. Various approaches of nanosizing

Kết quả (Anh) 2:

Spinning disc reactor (SDR) is one ofthe multifunctional devices
fast and homogenous mixing cung mà in a continuous operation.
Past research studies as an intensified SDR có proposed
for heat and mass transfer reactor limitation process [1-5] and am also
it is widely used for co-precipitation process fast như precipitation
of silver, lithium carbonate, copper oxide and chitosan [6- 9].
Seemed like similar Basicprinciple of SDRis fallingfilmevaporators.
In the fallingfilm evaporator, thin tube on the wall falling liquidfilm
the heat transfer coefficient Improves. In the case of SDR còn,
sheared thin film on the rotating disc is responsible for Higher heat
and mass transfer coefficient [1,4,10,11].
SDR is a horizontal principally vertical fast moving or rotating disc in a circular chamber.
Whenliquidis introducedonthe center of rotatingdisc, a thinliquid
Abbreviations: SDR, a spinning disc reactor; NS-S, non-solvent to solvent; S-NS,
solvent and non-solvent; PDI, polydispersity index; PSD, particle size distribution;
PVP, polyvinylpyrilodine.
* Corresponding author. Tel .: [phone]; fax: [phone].
E-mail addresses: [e-mail], [e-mail]
(VK Rathod).
vẻ on the disc surface film under the Influence of High centrifugalforce
whichprovides larger contact surface betweenmixing
fluid. At the same time,
Centrifugal force responsible for shear am also the between disc surface and liquid leads to wave and ripple formation
on the film and generates large volumes of smaller eddies throughout.
These are responsible for speedy Phenomenon and uniform
mixing of fluid on the disc [7.12 to 14]. In the present work, the SDR is
used for the continuous Preparation of curcumin nanoparticles via
solvent-nonsolvent (S-NS) precipitation.
Curcumin is a yellow compound hydrophobic polyphenols
extracted from the rhizome mà herb of the Curcuma
longa. Curcumin has wide therapeutic application Varieties of
như an anticancer, anti-inflammatory, antioxidant, antiulcer,
immunomodulatory, wound healing, neuroprotective, and antiaging
agents [15,16].
These ích applications of curcumin are limited by nó hydrophobicity (Solubility of pure curcumin in water
0.2 mg L-1). Hydrophobic nature of curcumin hinders successful ITS
Due to limited use dissolution and bioavailability Hence Lesser.
Nanosizing is one of the amongst the most attractive TECHNIQUES
commonly used methods to mitigate poor dissolution problem drug.
Reduced particle size increases the surface area by nanosizing
and enhances the Solubility and bioavailability Eventually of the
poorly soluble drug component. Various Approaches of nanosizing Hydrophobic nature of curcumin hinders successful ITS Due to limited use dissolution and bioavailability Hence Lesser. Nanosizing is one of the amongst the most attractive TECHNIQUES commonly used methods to mitigate poor dissolution problem drug. Reduced particle size increases the surface area by nanosizing and enhances the Solubility and bioavailability Eventually of the poorly soluble drug component. Various Approaches of nanosizing Hydrophobic nature of curcumin hinders successful ITS Due to limited use dissolution and bioavailability Hence Lesser. Nanosizing is one of the amongst the most attractive TECHNIQUES commonly used methods to mitigate poor dissolution problem drug. Reduced particle size increases the surface area by nanosizing and enhances the Solubility and bioavailability Eventually of the poorly soluble drug component. Various Approaches of nanosizing Reduced particle size increases the surface area by nanosizing and enhances the Solubility and bioavailability Eventually of the poorly soluble drug component. Various Approaches of nanosizing Reduced particle size increases the surface area by nanosizing and enhances the Solubility and bioavailability Eventually of the poorly soluble drug component. Various Approaches of nanosizing

Kết quả (Anh) 3:

Spinning disk reactor (SDR) is a ofthe multifunctional deviceThis provides a fast and homogenous mixing in continuous operation.Past studies have shown that the proposed SDR as intensifiedReactor for heat and mass transfer process also limitation] and [1 - 5It is widely used in fast shrinking alcohol precipitation process, such as alcohol precipitation methodLithium carbonates, silver, copper oxide and chitosan 6 - [9].Basicprinciple sdris seems similar to fallingfilmevaporators.At fallingfilm evaporator drop, thin tube wall to liquidfilmImproves heat transfer coefficient. And in the case of sdr,Films on sheared thin discs are responsible for higher thermal rotating1,4,10,11 and mass transfer coefficient []. Principally SDR is a horizontalFast moving or vertical rotating disk in a circular interior.Whenliquidis introducedonthe center rotatingdisc, thinliquidAbbreviations:sdr, spinning disk reactor; non solvent S NS, NS large solvent -.Solvent and non solvent; PDI, polydispersity PSD, particle size distribution index.PVP, polyvinylpyrilodine.For to the corresponding author. Tel. [phone] Fax: + + + 91, + 91, + 3361102022.Email address: vk.rathod @ @ ictmumbai.edu.in, virendrakrathod baskerville.hdtv(rathod V.K.).The film appears on the disc surface under the influence of high centrifugalforceLarger surface contact betweenmixing whichprovidesFluid. At the same time, also for the centrifugal air force is responsible for shearThe formation of waves between surfaces and large disks and ripple liquidIn movies and generates large smaller eddies whole.These phenomena are responsible for fast and uniformMixing fluid 7,12 - 14 disk [pair]. In the current work, is SDRNanoparticles for continuous preparation of CurcuminSolvent - nonsolvent (S - NS) alcohol precipitation method.Curcumin is yellow polyphenol hydrophobic compoundThis is the rhizome mining research extracted from the herb CurcumaLonga. Curcumin has a wide variety of therapeutic and its applicationSuch as Ann anticancer, anti inflammatory, antioxidant, antiulcer,Immunomodulatory, wound healing, neuroprotective, and Antiaging15,16 agent []. These applications are useful for curcuminLimited by its hydrophobicity (solubility pure curcumin in water)L - 10.2 mg). Its successful hinders curcumin hydrophobic propertiesDue to limited use, so bioavailability dissolution and small.Nanosizing is an attractive technology in mostMethods are usually used drugs dissolution mitigate poor big problem.Reduction of nanosizing particle size by increased surface areaAnd finally enhances solubility and bioavailability researchPoorly soluble drug components. Various methods of nanosizing