Antidepressant-Like Effects of Sars

Antidepressant-Like Effects of Sarsasapogenin from
Anemarrhena
asphodeloides
B
UNGE
(Liliaceae)
Li-Xiang R
EN
, Yi-Fan L
UO
, Xia L
I
, Dai-Ying Z
UO
, and Ying-Liang W
U
*
School of Pharmacy 41 mailbox, Shenyang Pharmaceutical University; Shenyang, 110016, China.
Received June 18, 2006; accepted July 26, 2006
The aim of this study was to investigate the effects of sarsasapogenin from
Anemarrhena asphodeloides
B
UNGE
(Liliaceae) on the forced swimming test, and the central noradrenergic, dopaminergic and serotonergic
activities in mice. Our results showed that sarsasapogenin treatment at 12.5, 25 and 50 mg/kg (
p.o.
) for 14 d sig-
nificantly reduced the duration of immobility in the forced swimming test. These doses that affected the immo-
bile response did not affect locomotor activity. In addition, the neurochemical assays showed that sarsasapogenin
produced a marked increase of noradrenaline and serotonin levels at 50 mg/kg in both the hypothalamus and the
hippocampus. Moreover, sarsasapogenin showed a monoamine oxidase inhibitory activity in the mouse brain.
These findings suggest that the antidepressant activity of sarsasapogenin may involve the central monoaminergic
neurotransmitter systems

Kết quả (Anh) 1:

Antidepressant-Like Effects of Sarsasapogenin from AnemarrhenaasphodeloidesBUNGE(Liliaceae)Li-Xiang REN, Yi-Fan LUOXia, LIDai-Ying ZUO, and Ying Liang WU*School of Pharmacy 41 mailbox, Shenyang Pharmaceutical University; Shenyang, China, 110,016.Received June 18, 2006; accepted July 26, 2006The aim of this study was to investigate the effects of sarsasapogenin from Anemarrhena asphodeloidesBUNGE(Liliaceae) on the forced swimming test, and the central noradrenergic, dopaminergic and serotonergicactivities in mice. Our results showed that sarsasapogenin treatment at 12.5, 25 and 50 mg/kg (p.o.) for 14 d sig-nificantly reduced the duration of immobility in the forced swimming test. These doses that affected the immo-bile response did not affect locomotor activity. In addition, the neurochemical assays showed that sarsasapogeninproduced a marked increase of noradrenaline and serotonin levels at 50 mg/kg in both the hypothalamus and thehippocampus. Moreover, a monoamine oxidase inhibitory activity showed sarsasapogenin in the mouse brain.These findings suggest that the antidepressant activity of sarsasapogenin may involve the central monoaminergicneurotransmitters systems

Kết quả (Anh) 2:

Effects of antidepressant-Like Sarsasapogenin from
Anemarrhena
asphodeloides
B
UNGE
(Liliaceae)
Li-Xiang R
EN
, Yi-Fan L
UO
, Xia L
I
, Dai-Ying Z
UO
, and Ying-Liang W
U
*
School of Pharmacy 41 mailboxes, Shenyang Pharmaceutical University; Shenyang, 110016, China.
Received June 18, 2006; accepted July 26, 2006
The aim of this study was to Investigate the effects of sarsasapogenin from
Anemarrhena asphodeloides
B
UNGE
(Liliaceae) on the forced swimming test, and the central noradrenergic, dopaminergic and serotonergic
Activities in mice. Our results showed treatment có sarsasapogenin at 12.5, 25 and 50 mg / kg (
po
) for 14 d nificant
nificantly reduced the duration of immobility in the forced swimming test. These doses có tác the immo-
bile did not hưởng Locomotor activity response. In Addition, the neurochemical assays showed có sarsasapogenin
Produced a noradrenaline and serotonin nhãn tăng of levels at 50 mg / kg in both Show the hypothalamus and the
hippocampus. Moreover, monoamine oxidase inhibitory sarsasapogenin showed a mouse activity in the brain.
These findings đề là antidepressant activity of sewing to involve the central sarsasapogenin monoaminergic
neurotransmitter systems