Enterococci, commensal inhabitants

Enterococci, commensal inhabitants of the intestinal and genital tracts, are rising in prominence as hospital pathogens.2 This rise is related to their natural
resistance to most commonly used antibiotics and their
capacity to acquire resistance to other antibiotics either
by mutation (penicillins) or by transfer of resistance
genes on plasmids and transposons (aminoglycosides
and glycopeptides).2 3 In the United States acquired
vancomycin resistance has increased more than
20-fold among nosocomial isolates of enterococci,
from 0.3% in 1989 to 10% in 1995.2 This rise paralleled
a massive increase in the use of vancomycin in US hospitals and was associated with spread of resistance
plasmids and transposons among multiple strains of
Enterococcus faecium and E faecalis.2 11 In addition,
epidemics of infection with vancomycin resistant enterococci broke out, initially in intensive care units and
later in whole hospitals.11–13 Most of these vancomycin
resistant strains are resistant to all other effective antimicrobials. In patients with bacteraemia due to these
strains, the mortality attributable to the infection is
substantial.14 In Europe the incidence of infection
caused by multiple resistant enterococci remains lower,
although several outbreaks have been reported in
transplant and intensive care units.15 About 2-5% of the
population in Europe are intestinal carriers of
vancomycin resistant E faecium, presumably acquired
from the food chain.16

Kết quả (Anh) 2:

Enterococci, commensal inhabitants of the intestinal and genital tracts, are rising in prominence as pathogens.2 This rise is related hospital to ask for their natural
resistance to antibiotics and spend the weekend Most commonly USED
Capacity to Acquire resistance to other antibiotics hoặc
by mutation (penicillins) or by transfer of resistance
genes on plasmids and transposons (aminoglycosides
and glycopeptides) .2 3 In the United States acquired
vancomycin resistance has more coal Increased
20-fold nosocomial isolates of enterococci Among,
from 0.3% in 1989 to 10% in 1995.2 This rise paralleled
a Massive Increase in the use of vancomycin in US Hospitals and was associated with the spread of resistance
plasmids and transposons Among multiple strains of
Enterococcus faecium and E faecalis.2 11 In addition,
epidemics of infection with vancomycin-resistant enterococci broke out, initially in intensive care units and
later in whole hospitals.11-13 Most of những vancomycin-
resistant strains are resistant to all other antimicrobials effective. In Patients with bacteraemia Due to these
strains, the mortality attributable to the infection is
substantial.14 In Europe the incidence of infection
caused by multiple resistant enterococci Remains Lower,
although vài Outbreaks Reported in past tense
transplant and intensive care units.15 About 2- 5% of the
population in Europe are intestinal carriers of
vancomycin-resistant E faecium, presumably acquired
from the food chain.16