Endostatin: an endogenous inhibitor

Endostatin: an endogenous inhibitor of angiogenesis and tumor growth.
O'Reilly MS1, Boehm T, Shing Y, Fukai N, Vasios G, Lane WS, Flynn E, Birkhead JR, Olsen BR, Folkman J.
Author information
Abstract

We previously identified the angiogenesis inhibitor angiostatin. Using a similar strategy, we have identified endostatin, an angiogenesis inhibitor produced by hemangioendothelioma. Endostatin is a 20 kDa C-terminal fragment of collagen XVIII. Endostatin specifically inhibits endothelial proliferation and potently inhibits angiogenesis and tumor growth. By a novel method of sustained release, E. coli-derived endostatin was administered as a nonrefolded suspension. Primary tumors were regressed to dormant microscopic lesions. Immunohistochemistry revealed blocked angiogenesis accompanied by high proliferation balanced by apoptosis in tumor cells. There was no toxicity. Together with angiostatin data, these findings validate a strategy for identifying endogenous angiogenesis inhibitors, suggest a theme of fragments of proteins as angiogenesis inhibitors, and demonstrate dormancy therapy.

PMID:
9008168

Kết quả (Anh) 1:

Endostatin: an endogenous inhibitor of angiogenesis and tumor growth.O'reilly MS1, Boehm T, Shing Y, Fukai N, Vasios G, Lane WS, Flynn E, Birkhead JR, Olsen BR, Folkman J.Author informationAbstractWe previously identified the angiogenesis inhibitor angiostatin. Using a similar strategy, we have identified endostatin, an angiogenesis inhibitor produced by hemangioendothelioma. Endostatin is a 20 kDa C-terminal fragment of collagen XVIII. Endostatin inhibits endothelial proliferation specifically and potently inhibits angiogenesis and tumor growth. By a novel method of sustained release, e. coli-derived endostatin was administered as a suspension nonrefolded. Primary tumors were regressed to dormant microscopic lesions. Immunohistochemistry revealed blocked angiogenesis accompanied by high proliferation balanced by apoptosis in tumor cells. There was no toxicity. Together with angiostatin data, these findings validate a strategy for identifying endogenous angiogenesis inhibitors, suggest a theme of fragments of proteins as angiogenesis inhibitors, and demonstrate dormancy therapy.PMID: 9008168

Kết quả (Anh) 2:

Endostatin: an endogenous inhibitor of angiogenesis and tumor growth.
O'Reilly MS1, Boehm T, Shing Y, Fukai N, Vasios G, Lane WS, E Flynn, JR Birkhead, Olsen BR, Folkman J.
Author information
Abstract

We trước Identified the angiogenesis inhibitor angiostatin. Using a similar strategy, WE HAVE Identified endostatin, an angiogenesis inhibitor Produced by hemangioendothelioma. Endostatin is a 20 kDa C-terminal fragment of collagen XVIII. Endostatin specifically inhibits endothelial proliferation and potently inhibits angiogenesis and tumor growth. By a novel method of sustained release, E. coli-derived endostatin was Administered as a nonrefolded suspension. Primary tumors regressed to Dormant microscopic lesions là. Immunohistochemistry revealed blocked angiogenesis accompanied by high proliferation apoptosis in tumor cells by Balanced. There was no toxicity. Together with angiostatin data, findings validate a strategy for những endogenous angiogenesis inhibitors Identifying, Suggest a theme of fragments of proteins as angiogenesis inhibitors, and proven and demonstrated dormancy therapy.

PMID:
9008168